The early interaction (1945-1948) between China and World Health Organization (WHO) was the first attempt of China to have actively engaged in international health governance. As a founding member, China initiated the proposal of founding WHO and participated in the whole process of its establishment, during which China had contributed Chinese wisdom and diplomatic skills in terms of naming, organization structure and guiding principles. As one of the major cooperators with the WHO’s transitional committee, China had worked together with WHO in containing epidemics and nurturing talents. However, due to the lack of resources, war and chaos, and the change of international and domestic politics, it was more of assistance rather than cooperation, and there were not obvious practical effects. In the process of the establishment and development of the WHO’s office in the Western Pacific, regretfully few contributions came from China.